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  • 专利说明
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    • 专利摘要:
    Mobile system for obtaining molecular images and intervention system that includes it. The present invention relates to a mobile system for obtaining molecular images, for example a pet device (positron emission tomography) or spect (single photon emission computed tomography), comprising: - at least one group of n detector modules comprising sets of detector modules with a rounded shape comprising m detector modules each, where m <n and so that said sets of detector modules are separable from each other, - first means to carry out the movement of separation of the sets of detector modules in the transaxial plane - second means for carrying out a rotational movement of the imaging system - a vertical actuator that allows the movement of the imaging system And also refers to an intervention system comprising the mobile system for obtaining molecular images and the use of any of them in medical procedures, such as biopsy, radiotherapy, radiofrequency or ultrasound, among others. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2634027A1
    申请号:ES201630226
    申请日:2016-02-26
    公开日:2017-09-26
    发明作者:Jorge ÁLAMO VALENZUELA；Carlos Correcher Salvador；Julio BARBERÁ BALLESTER；José MARTÍNEZ BENEDICTO
    申请人:General Equipment for Medical Imaging SA；
    IPC主号:
    专利说明:

    Mobile molecular imaging system and intervention system comprising it
    Field of the Invention
    The present invention is framed in the field of medical procedures that use molecular imaging techniques and more particularly, to associated intervention devices and guided by a mobile molecular imaging system, such as guided biopsy, radiofrequency or ultrasound, or radiotherapy, among others.
    Background of the invention
    Imaging techniques applied in medicine visualize the interior of living organisms, allowing an accurate and early diagnosis that substantially affects the strategies in therapy, which improves the outcome of the treatment and reduces the mortality and morbidity of multiple diseases. Its importance lies in several areas of health and research, such as the diagnosis of cancer and its staging, the evaluation of the cardiovascular system and in multiple applications of neuroscience and molecular genetics.
    In this context, thanks to its inherent molecular characteristics (able to observe concentrations between nano-molars and picomolars) and its excellent sensitivity, Nuclear Medicine plays an important role in providing functional information in three dimensions in vivo (3D) in the biodistribution of a molecular tracer labeled with radioactive isotopes (ie, a radiopharmaceutical) administered to the study subject 11].
    Currently, nuclear medicine is a clinical instrument widely used in oncology, cardiology and neurology 12] 13] 14] 15]. Most of the commercial equipment allows to obtain images of the entire body of the patients, although equipment dedicated to obtaining images of specific organs has recently appeared] 6].
    A current limitation of nuclear medicine techniques is its practically only application for diagnosis because current equipment has geometries that are hardly compatible with any type of intervention in the patient during exploration. Neither the entire body equipment nor the equipment dedicated to organs with closed configurations have the ability to visualize or track any intervention on the patient in real time
    There are medical imaging techniques that allow seeing or following interventions, but are limited to structural images such as CT (computed tomography), MR (magnetic resonance imaging) or ultrasound, in which the morphology of the organ that can be observed is observed. It will be intervened, but not the biological functionality that a nuclear medicine system would be able to view [7]. Many of these systems also do not allow real-time monitoring, but only take pictures at different times of the process to ensure that the intervention is carried out at the desired morphological point. Ultrasound-based systems are an exception, obtaining real-time images, but with very low resolution and specificity.
    For example, during MR-guided tumor biopsies, common in clinical practice, the user obtains an image of the patient within a full-body equipment, through which the point to be biopsied is determined. The patient is removed from the equipment using a motorized stretcher to introduce a guide in the organ at the desired biopsy point and then to introduce the patient into the equipment to obtain a confirmation image. After confirmation, the patient leaves the equipment again and the biopsy is carried out 18].
    Description of the invention
    Definitions and abbreviations used in this report ·
    "Mobile molecular imaging system": refers to a system for imaging using radiation, for example, gamma radiation, which is abbreviated as "imaging system"
    "Intervention device" means a device or device intended to carry out an intervention on a patient's organ or on the patient's body, such as a biopsy, radiofrequency, radiotherapy or ultrasound device, between others, and that is associated with the mobile molecular imaging system
    "Semi-ring": This is a set of detector modules with a semi-circumference shape or semi-ellipse shape or also called the OC shape. "In the case of a PET device (positron emission tomography) it can also be called a "semi-PET ring" or "PET group"
    ~ Intervention system ": refers to a system that combines the mobile molecular imaging system and the intervention device.
    MAsociadoH means that the intervention system can be mechanically connected to the mobile molecular imaging system or can simply be guided by the mobile molecular imaging system by using a common reference coordinate system
    ~ Biopsy system "," guided biopsy set ~ and "biopsy device" are expressions used interchangeably
    ~ Intervention procedure "and" medical procedure "are expressions used interchangeably and refer to a series of stages aimed at interfering with the outcome or process, especially of a disease or a procedure - such as to prevent damage or improve function
    M Intervention tool: refers to any instrument or tool that will be used in the medical procedure
    The present invention relates to a mobile molecular imaging system comprising:
    ~ at least one group of n detector modules that form sets of detector modules with a rounded shape comprising m detector modules each, m <n and so that said detector module sets are separable from each other,
    - first means for carrying out the separation movement of the detector module assemblies in the transaxial plane
    • second means for carrying out a rotation movement of the imaging system - a vertical actuator that allows axial movement of the imaging system
    According to particular embodiments, the rotation movement of the imaging system is a rotation about an axial axis - usually the Z axis - of the detector module assemblies In the imaging system of the invention, according to Particular additional realizations:
    - the first means are · -first mechanical supports to carry out the separation movement of the module assemblies
    Transaxial detectors-a horizontal actuator to move the mechanical supports in opposite directions and-a manual handle associated with the horizontal actuator
    - and said second means are: - a rotating mechanical support for carrying out the rotational movement of the imaging system around an axial axis - a manual handle associated with the rotating mechanical support In the imaging system of the invention, in accordance with additional particular embodiments:
    • The first means are: -first mechanical supports to carry out the separation movement of the module assemblies
    Transaxial plane detectors - a horizontal actuator to move the mechanical supports in opposite directions and - a motor associated with the horizontal actuator
    - and said second means are · -a rotary mechanical support for carrying out the rotational movement of the imaging system
    - a motor associated with the rotating mechanical support. According to more particular embodiments the second means are
    - a rotary mechanical support for carrying out the rotational movement of the imaging system around an axial axis - normally the Z axis - of the detector module assemblies and -a motor associated with the rotary mechanical support.
    According to particular embodiments, the sets of m detector modules are in the form of a ring fragment, including the possibility of being an ellipse fragment, and preferably, they are in the form of semi-rings, semi-ellipse or e-shaped structures, which comprise n / 2 detector modules each.
    An imaging system may comprise one or more groups of detector modules, for example, it may comprise two overlapping groups, each of these groups consisting of at least two sets of detector modules.
    The molecular mobile imaging system can be selected between a SPECT (single photon emission computed tomography), and a PET device, and more preferably it is a PET device
    The imaging system according to particular embodiments is a PET device or a SPECT device, preferably a PET device, in which the detector modules can have the characteristics of conventional devices with respect to the type of crystals. For example, they can comprise monolithic or pixelated scintillation crystals, like any conventional device. Any type of continuous scintillation crystal known in the art can be used in terms of shape and composition. The monolithic scintillation crystals, for example L YSO (lutetium and yttrium oxyorthosilicate), can be -in particular embodiments-, trapezoidal monolithic scintillation crystals The scintillation crystals can be coupled to any known photomultiplier or matrix photomultiplier appropriate, for example PSPMTs (position sensitive photomultiplier tubes).
    The imaging system can rotate up to 360 degrees and can be placed in a configuration in which the sets, preferably semi-rings, of detector modules, are separated up to a distance equivalent to the diameter of the half-ring (ring diameter formed by the two semi-rings), or to the larger diameter in the case of detector sets {groups of detectors with an ellipse shape.
    According to particular embodiments, the imaging system rotates up to 1800 and can be placed in a configuration in which the assemblies, preferably semi-rings of detector modules, are separated up to 100 mm.
    The present invention also relates to an intervention system comprising the image obfenction system described above and to an intervention device, which is as defined above, a device or apparatus intended to carry out an intervention in an organ of a patient or the patient's body and that is associated with the mobile molecular imaging system. The term ~ associatedH has the meaning given above: that is, that the imaging system can be mechanically linked to the mobile molecular imaging system or can simply be guided by the mobile molecular imaging system through the use of a common reference system, which can be placed, for example, in a biopsy rack
    Particular embodiments of the intervention device refer to a radiotherapy device, a radiofrequency device, a brachytherapy device, a proton therapy device, an ultrasound device, a HIFU (high frequency focalised ultrasound) or a guided biopsy set (or surgical).
    The intervention system, according to preferred embodiments, includes a first processing device capable of reconstructing the information acquired by the imaging system in three-dimensional images of the distribution of a radioactive marking in the field of vision (field-of- view). This processor is capable of reconstructing images in any location of the imaging system in all configurations (open, closed, rotated, etc.).
    The first processor is capable of reconstructing images with a sufficient renewal rate to guide the intervention process (for example, for a particular embodiment referred to a biopsy device, 2 images per second might be suitable).
    The intervention system, according to preferred embodiments, includes a second processing device capable of calculating the optimal trajectory of the intervention device in the patient's body or organ, based on a single location, for example, the lesion from which it is leaving. to do the biopsy (selected by the user) in the image obtained by the first processor. The trajectory is restricted to the available positions attainable by the intervention system.
    The intervention system may also include a support to support the patient's desired body or part of the body during the intervention to avoid unwanted movements of the organ. For example, two paddles can hold the organ, for example a breast, with gentle compression during the procedure or procedure.
    The intervention system can be operated manually or it can be operated through actuators, which mechanically link the imaging system to the intervention device
    In the particular case of a guided biopsy assembly, it may comprise several mechanical actuators, which allow a needle to move in the three spatial directions. The imaging system is compatible with a commercial biopsy system. The imaging system may also include a laser device that can locate the tip of the needle to ensure the precise location of the needle before starting the procedure.
    Particular embodiments of a guided biopsy set are a biopsy device associated with a PET device, and a biopsy device associated with a SPECT device.
    The invention also relates to the use of the imaging system or the use of the Intervention System, for example a guided biopsy set described above, to carry out an intervention on the body of a patient, for example a biopsy procedure.
    The use of the Intervention System of the invention comprises the following steps ·
    - a first stage that involves obtaining first images with the imaging system,
    - a second stage, comprising moving the imaging system in the axial direction by positioning a first set of detector modules with the appropriate path path for an intervention tool,
    - a third stage, in which the sets of detector modules, such as sets of detector modules in the form of semi-rings, are fixed and the intervention device is actuated
    The intervention system may comprise a processing device that generates images during a medical procedure or intervention process. These images can also be generated during the intervention process in real time.
    Particular embodiments of the use of the Intervention System of the invention, comprise the following steps:
    - a first stage that consists of making first images such as an initial exploration of a part of the body {organ that is going to be intervened,
    - a second stage, comprising moving the imaging system in the axial direction, positioning the upper groups of semi-rings in a PET with two groups of superimposed detector modules, in the selected region of interest, rotating the first half-ring of detector modules, to align a C-ring opening with the appropriate path path for the intervention tool, for example a needle, and make new sweeps,
    - a third stage, in which the semi-rings are fixed to avoid any rotation or movement during the intervention, for example, a biopsy procedure, and to carry out the intervention, for example a biopsy.
    The images are obtained in several steps to ensure the correct location of the intervention tool, for example a needle, during the intervention.
    The third stage also includes making short acquisitions of images (about 2 minutes) and correcting the orientation of the intervention tool, for example, a needle, if necessary
    The process of using the intervention system of the invention can refer in a particular case to the use of an intervention device with its own mechanical properties that make it capable of placing itself in the desired position, for example, a set of guided biopsy combined with a PET device. The PET device may comprise two superimposed sets of semi-rings of detector modules (as in Fig. 7) that can be mechanically separated in order to allow needle insertion. The first acquisition of images of the patient's organ, for example of the breast, is performed with the co-configuration of the closed ring in order to obtain a high quality image to locate the lesion. Then, the software calculates the optimal route for the biopsy and moves the biopsy and PET systems to the desired position. At this point, two compression paddles are used to support the breast. Then, the PET system opens and the biopsy procedure begins.
    According to particular embodiments of a guided biopsy device, it may be provided with a vertical elevator, or vertical actuator, which co-moves the detectors of the imaging system and the biopsy device in order to allow the biopsy needle to locate the optimal axial position to start the procedure
    The imaging system of the invention is capable of producing high quality images in its closed configuration and has the ability to separate the detectors to allow the biopsy needle to enter the field of vision (FOV). Although the quality of the image with the open configuration degrades compared to the closed configuration, it is more than enough to carry out the biopsy procedure, since the image is only used as a guide to locate the lesion.
    Brief description of the figures
    Fig. 1A depicts a particular embodiment of a closed 3D configuration of the imaging system of the invention, a PET device, with a group of detector modules composed of two sets of detector modules that have a semi-ring shape, according with the invention
    Fig. 18 represents a perspective view from above, of the same closed 3D configuration of the PET device shown in Fig. 1 A.
    Fig. 2 represents a front view of the closed 3D configuration of the same embodiment shown in Fig. 1A and Fig 1B
    Fig. 3 represents a top view of the closed configuration of the same embodiment shown in Fig. 1A YFig 1B
    Fig. 4 depicts a front view of the open 3D configuration of the same embodiment shown in Fig. 1A and Fig. 18.
    Fig. 5 represents a front view of the complete 3D configuration rotated with respect to the configuration shown in Fig. 4, corresponding to the same embodiment as Fig. 1A YFig. 18.
    Fig. 6 depicts a front view of the open 3D configuration (below) of the same embodiment as shown in Fig. 1A YFig. 1 B.
    Fig. 7 represents an example of an imaging system, a PET, with two groups of superimposed detectors, each of these groups is composed of two sets of semi-ring shaped detector modules, specifically a front view is shown of the complete 3D imaging system corresponding to the same embodiment as Fig. 1A YFig. 1 B, but in an open configuration.
    Fig. 8 represents a full open 3D configuration front view, corresponding to the same embodiment as Fig. 1A YFig. 18
    Fig. 9 represents a full open 3D configuration front view (below) corresponding to the same realization as Fig. 1AyFig. 18
    Fig. 10 represents a front view of the open configuration corresponding to the same embodiment as Fig. 1A and Fig. 1B.
    Fig. 11 represents a top view of the open configuration corresponding to the same embodiment as Fig. 1A and Fig. 1 B.
    Fig. 12: represents an imaging device, a PET, in which a support can be seen to hold an organ of a patient, part of the body, for example, a pair of paddles to hold a breast during a biopsy procedure and the needle of a biopsy device associated with PET.
    Fig. 13. (A to E) represents a chronological sequence of positions of an example intervention system of the invention during its use
    References used in the figures:
    • 1 semi-ring PET f PET Group
    • 2 Mechanical support to carry out the separation movement of the two semi-rings
    • 3 horizontal actuator to carry out the separation movement of the two half-rings Allows each of the two mechanical supports to go in an opposite direction
    • 4 Horizontal actuator motor
    • 5. Mechanical support to carry out the rotation movement of the assembly
    • 6. Rotating mechanical support motor
    • 7. The vertical actuator that allows the movement of the assembly with respect to that axis.
    • 8 Needle in a biopsy device associated with a PET device
    • 9. Support to hold the patient's organ or body part.
    Example
    A particular embodiment of the molecular imaging system is a PET device like the one shown in Figure 7, which comprises two superimposed sets of half-rings of detector modules (two upper half-rings and two lower half-rings) with the same number of detector modules each semi-ring, preferably 6 detector modules each.
    In accordance with this specific embodiment, a PET system is provided consisting of two rings with 12 modules each. Each module contains a single continuous LYSO scintillation crystal coupled to a PS85T H8500 from Hamamatsu Photonics (Hamamatsu City, Japan) and dedicated electronics. The use of trapezoidal crystals reduces the effect of image compression and improves energy, and the spatial resolution and interaction depth
    (001) especially when considering truncation of angles less than 600. The mobile molecular imaging system · here a PET with detector modules that form semi-rings ·, has an opening of 186 mm.
    The detector design uses 12mm thick LYSO scintillation crystals, whose front and back are 40 x
    40 mm and 50 x 50 mm2, respectively. The rear face of the crystals is polished and 0.25 mm apart from the PSPMTs. All other glass surfaces are rough and painted black.
    The image acquisition system (semi-rings + electronics + computer) consists of a trigger card, responsible for detecting the coincidence events, and several separate AJO conversion cards. The conversion is initiated by the activation rate when two events are detected in a time window of 5 ns. A rear electronic board connects the firing rate, the GARLIC cards and the signaling routes.
    Matches between each detector and its seven opposing detector modules are allowed, providing a transaxial FOV (field of view) of 170 mm. The axial FOV covers 94 mm. A precise vertical lift moves the detector and the biopsy device together to allow the biopsy needle to be placed in the optimal axial position to start the procedure.
    The biopsy device is composed of several mechanical actuators, which allow a needle to move in the three spatial directions. The system is compatible with commercial biopsy systems. It also includes a laser device that can locate the tip of the needle to ensure precise location of the needle before starting the biopsy procedure.
    To enable the biopsy procedure, PET detectors are separable up to 60 mm in the transaxial direction, becoming two groups of 6 detectors that form a form of HC ~, which allows the passage of the needle (Figure 12). In addition, the system can rotate up to 170 degrees to position the half-rings of detectors in the optimal location to minimize the path of the biopsy to the lesion. The system includes two pallets for
    hold the breast during the biopsy procedure.
    The protocol defined to perform a breast examination with biopsy consists of three stages each corresponding to a different position of the PET device (Figure 13). The first stage consists of an initial examination of the complete breast with the co-configuration closed of the detector, generating a high quality image in order to determine the location of the lesion. In the second stage, the detector system moves in the axial direction by positioning the upper ring in the selected region of interest. Next, the detector rings rotate to align the C ring opening with the shortest path path in order to insert the needle into the breast. The rings open and the paddles fix the breast. The detector system makes new acquisitions and relocates the location of the lesion in the 3D image, since the compression of the palette should displace the original location of the lesion. In the last stage, the ring is fixed to avoid any rotation or movement during the medical procedure. The biopsy starts and the system makes short acquisitions (about 2 minutes) to monitor the position of the lesion and the needle, making several stages to reach the final location, always supervised and controlled by the user. The orientation of the needle can be corrected at each stage if necessary.
    An examination table is available, where the patient is in the prone position. A PET system according to the invention is used together with a complete biopsy device. Two transparent polycarbonate vanes are included (Figure 12) to hold the breast during the biopsy procedure and all the motors necessary to move the different components, including the opening and rotation of the PET half-rings.
    In the back area of the PET device, the acquisition computer and the electrical and electronic components are located. The acquisition and reconstruction software is located in a separate portable car, which includes a workstation with a data storage system, two monitors and a medical grade keyboard
    References
    p] S. Cherry, J A. Sorenson and M. Phelp, Physics in Nuclear Medicine, Philadelphia, PA: W.B. Saunders, Elsevier Science, 2003
    [2] S. David, M. Hatt and D. Visvikis, «Mu / ti Observation PET / mage Fusion for Patient Follow Up Quantitation in 5 Oncology, ll Med. Phys., Vol. 38, p. 3454, 2011
    p] E. Ford, P. Kinahan, L Hanlon, A. Alessio, J. Rajendran, D. Schwartz and M. Phillips, "Tumor delineation using PET in head and neck cancers: Threshold contouring and / esion vo / umes" Med Phys., Vol. 33, p. 4280, 2006.
    [4] Y. Tai and P. Piccini, "Applications of positron emission tomography (PET} in neur% g'j" J. Neural. Neurosurg. Psychialry, vol. 75, pp. 669-676, 2004.
    10 [5] M. Di Carli, S. Dorbala, J. Meserve, G. Fakhri, A. Sitek and S. Moore, "Glinica / Myocardial Pelfusion PET / CT" J NucL Med., Vol. 48, p. 783 --- 793, 2007
    [6] L Moliner, A. González, A. Soriano, C Correcher, A. Orera, M. Caries, L Vidal, J. Barbera, L Caballero, M. Seimelz, C. Vazquez and J. Benlloch, «Design and Eva / uation of the MAMMI dedicated breast PET »Med. Phys., Vol. 39, No. 9, 2012.
    15 (7) Dillon, MF, MB, MRCSI, al. "The Accuracy of U / trasound, Stereotactic, and Cfinical Core Biopsies in the Diagnosis of Breast Cancer, With an Ana / ysis of False-Negative Cases." Ann Surg 2005 November; 242 (5): 701-707.
    [81 http: //www.radiologyinfo.Ofgfenfinfo.cfm Pg = breaslbimr
    权利要求:
    Claims (9)
    [1]
    A mobile molecular imaging system comprising · -at least one group of n detector modules that form sets of detector modules with a shape
    rounded, comprising m detector modules each, m <n and so that said detector module assemblies are separable from each other, - first means for carrying out the separation movement of the detector module assemblies in the
    transaxial plane-second means for carrying out a rotation movement of the imaging system-a vertical actuator that allows axial movement of the imaging system.
    [2]
    2. The imaging system according to claim 1, wherein, -the first means are · -first mechanical supports for carrying out the separation movement of the module assemblies
    Transaxial detectors-a horizontal actuator to move the mechanical supports in opposite directions and-a manual handle associated with the horizontal actuator
    - and said second means are - a rotating mechanical support for carrying out the rotational movement of the imaging system around an axial axis - a manual handle associated with the rotating mechanical support. The imaging system according to claim 1, wherein -the first means are · -first mechanical supports for carrying out the separation movement of the module assemblies
    Transaxial detectors-a horizontal actuator to move the mechanical supports in opposite directions and-a motor associated with the horizontal actuator
    - and said second means are - a rotating mechanical support for carrying out the rotation movement of the imaging system - an engine associated with the rotating mechanical support.
    [4]
    Four. The imaging system according to claim 1 or 2, wherein the sets of n detector modules are in the form of a ring fragment or an ellipse fragment.
    [5]
    5. The imaging system according to claim 1 or 2, wherein the sets of n detector modules are ring-shaped and are forming structures that are semi-rings comprising nf2 detector modules each.
    [6]
    6. The imaging system according to any one of the preceding claims, which is selected between a SPECT device and a PET device.
    [7]
    7. The imaging system according to any one of claims 2 or 3, wherein the rotating mechanical support rotates up to 180 degrees
    [8]
    8. The imaging system according to any one of claims 1 to 7, which includes a first processed device capable of reconstructing the information acquired by the imaging system in three-dimensional images of the distribution of a radioactive marker in the field of vision
    [9]
    9. An intervention system comprising the imaging system defined in any one of the preceding claims and an intervention device
    The intervention system according to claim 9, which includes a second processor capable of calculating the optimal path for an intervention device in the patient's body or organ, based on the image generated by the first processor and a region of interest selected.
    11 The intervention system according to any one of claims 9 to 10, which includes a support for holding an organ or part of the patient's body during an intervention
    12_ The intervention system according to any one of claims 9 to 11, which is manually operated or operated through actuators that mechanically link the imaging system to the intervention device.
    13_ The intervention system according to any one of claims 9 to 12, selected from a device for
    10 radiotherapy, a proton therapy device, a brachytherapy device, a radiofrequency device, a guided biopsy device, an ultrasound device and a high frequency ultrasound device -HIFU -.
    14_ Use of the imaging system defined in any one of claims 9 to 13 to carry out a medical procedure, comprising the following steps.
    - a first stage that consists of obtaining first images with the system of obtaining images
    15 -a second stage, which involves moving the imaging system in the axial direction, positioning a first set of detector modules with the appropriate path path for an intervention tool,
    - a third stage, in which the sets of detector modules are fixed are fixed and the intervention device is actuated
    [15]
    15. Use of the intervention system defined in one of claims 9 to 13, wherein the first processor of the imaging system generates images during the intervention process
    16_Using the intervention system according to claim 15, wherein the first processor of the imaging system generates images during the intervention process in real time.
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    同族专利:
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    ES2634027B1|2018-07-02|
    引用文献:
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